1 00:00:04,550 --> 00:00:03,110 uh june was vision research awareness 2 00:00:06,470 --> 00:00:04,560 month uh one of 3 00:00:08,070 --> 00:00:06,480 my colleagues here at uh nasa public 4 00:00:10,870 --> 00:00:08,080 affairs brandy dean actually got a 5 00:00:12,629 --> 00:00:10,880 chance to talk to one of the doctors 6 00:00:15,110 --> 00:00:12,639 involved in this research taking place 7 00:00:17,189 --> 00:00:15,120 on board the station she was able to 8 00:00:18,950 --> 00:00:17,199 actually get a personal demonstration 9 00:00:20,790 --> 00:00:18,960 and learn a little bit more about this 10 00:00:22,870 --> 00:00:20,800 research taking place on board the 11 00:00:24,470 --> 00:00:22,880 orbiting laboratory 12 00:00:26,550 --> 00:00:24,480 hi welcome to the flight medicine 13 00:00:28,070 --> 00:00:26,560 optometry clinic at johnson space center 14 00:00:30,150 --> 00:00:28,080 where in honor of flight research 15 00:00:31,830 --> 00:00:30,160 awareness month we are here talking with 16 00:00:33,190 --> 00:00:31,840 dr bob gibson who's one of our 17 00:00:34,389 --> 00:00:33,200 optometrists and he's going to tell us a 18 00:00:36,229 --> 00:00:34,399 little bit about some of the research 19 00:00:38,069 --> 00:00:36,239 we're doing with the crew members on 20 00:00:39,590 --> 00:00:38,079 station to find out what might be 21 00:00:41,670 --> 00:00:39,600 causing the vision problem some of them 22 00:00:43,670 --> 00:00:41,680 have when they return from long flights 23 00:00:45,430 --> 00:00:43,680 in space thanks so much for joining us 24 00:00:49,029 --> 00:00:45,440 bob glad to be here 25 00:00:50,470 --> 00:00:49,039 so let's see what what exactly um are we 26 00:00:51,510 --> 00:00:50,480 looking at here 27 00:00:53,830 --> 00:00:51,520 well 28 00:00:55,990 --> 00:00:53,840 this device here is uh 29 00:00:56,869 --> 00:00:56,000 known as optical coherence tomography 30 00:01:01,349 --> 00:00:56,879 which 31 00:01:02,790 --> 00:01:01,359 to look at the various structures in the 32 00:01:05,350 --> 00:01:02,800 back of the eye 33 00:01:07,030 --> 00:01:05,360 as you may be aware a significant number 34 00:01:09,109 --> 00:01:07,040 of our long-duration flyers have 35 00:01:11,350 --> 00:01:09,119 returned from space with structural 36 00:01:13,590 --> 00:01:11,360 changes to the eye we're seeing a 37 00:01:15,510 --> 00:01:13,600 swelling of the optic nerve 38 00:01:17,590 --> 00:01:15,520 wrinkles to the retina and the choroid 39 00:01:19,270 --> 00:01:17,600 in the back of the eye 40 00:01:20,469 --> 00:01:19,280 as well as far sided shifts in their 41 00:01:21,990 --> 00:01:20,479 vision 42 00:01:24,070 --> 00:01:22,000 and to better give us a better 43 00:01:26,070 --> 00:01:24,080 understanding 44 00:01:28,789 --> 00:01:26,080 for these structural changes we have 45 00:01:30,550 --> 00:01:28,799 this diagnostic tool again known as oct 46 00:01:31,590 --> 00:01:30,560 which allows us to 47 00:01:33,510 --> 00:01:31,600 measure the back of the eye 48 00:01:36,069 --> 00:01:33,520 non-invasively 49 00:01:39,590 --> 00:01:37,510 light instead of 50 00:01:42,469 --> 00:01:39,600 ultrasound 51 00:01:44,149 --> 00:01:42,479 ultrasonic devices which use sound waves 52 00:01:45,270 --> 00:01:44,159 we use light waves 53 00:01:46,789 --> 00:01:45,280 to 54 00:01:48,310 --> 00:01:46,799 look at the structures within the back 55 00:01:49,749 --> 00:01:48,320 of the eye within the retina within the 56 00:01:51,429 --> 00:01:49,759 optic nerve 57 00:01:53,190 --> 00:01:51,439 and look for the structural changes and 58 00:01:55,190 --> 00:01:53,200 detect them much much earlier than we 59 00:01:56,709 --> 00:01:55,200 would otherwise what kind of changes can 60 00:01:58,149 --> 00:01:56,719 you see with this what i guess what 61 00:02:00,950 --> 00:01:58,159 would we look for at the back of the eye 62 00:02:03,350 --> 00:02:00,960 well if i can demonstrate with the model 63 00:02:04,709 --> 00:02:03,360 of the eye here right 64 00:02:06,830 --> 00:02:04,719 here we have the front of the eye known 65 00:02:09,430 --> 00:02:06,840 as the cornea and if 66 00:02:11,270 --> 00:02:09,440 i show you a cross section through the 67 00:02:13,190 --> 00:02:11,280 eye here we have again the cornea we 68 00:02:14,869 --> 00:02:13,200 have the internal lining of the eye 69 00:02:16,309 --> 00:02:14,879 known as the retina 70 00:02:18,150 --> 00:02:16,319 all the nerve fiber layers and the 71 00:02:19,190 --> 00:02:18,160 retina come together that form the optic 72 00:02:20,949 --> 00:02:19,200 disc 73 00:02:22,790 --> 00:02:20,959 which leads to the optic nerve which is 74 00:02:23,910 --> 00:02:22,800 an extension of the brain 75 00:02:25,190 --> 00:02:23,920 and what we're seeing in our crew 76 00:02:27,350 --> 00:02:25,200 members are 77 00:02:28,710 --> 00:02:27,360 wrinkles or folds to the inner lining 78 00:02:30,710 --> 00:02:28,720 the retina 79 00:02:32,790 --> 00:02:30,720 to the layer known as the choroid behind 80 00:02:34,869 --> 00:02:32,800 the retina we're seeing folds in this 81 00:02:37,589 --> 00:02:34,879 region as well and we're also seeing 82 00:02:41,430 --> 00:02:37,599 swelling of the retina and of the optic 83 00:02:43,990 --> 00:02:41,440 disc again also known as the optic nerve 84 00:02:45,670 --> 00:02:44,000 and so this is a machine that can that 85 00:02:48,470 --> 00:02:45,680 allows you to see those things while the 86 00:02:50,710 --> 00:02:48,480 crew is still on orbit right that is 87 00:02:53,110 --> 00:02:50,720 correct it allows us to detect very 88 00:02:55,030 --> 00:02:53,120 subtle changes within just a few microns 89 00:02:57,589 --> 00:02:55,040 of change from what we measure 90 00:02:59,830 --> 00:02:57,599 preflight so we can detect these changes 91 00:03:01,830 --> 00:02:59,840 much much sooner and have a better way 92 00:03:04,229 --> 00:03:01,840 of monitoring these changes over time 93 00:03:06,630 --> 00:03:04,239 and giving us a better understanding for 94 00:03:08,630 --> 00:03:06,640 the mechanisms for these changes 95 00:03:10,550 --> 00:03:08,640 is this something uh like an exam that 96 00:03:12,630 --> 00:03:10,560 people here on earth would be taking 97 00:03:14,470 --> 00:03:12,640 normally as part of their eye exams it's 98 00:03:18,309 --> 00:03:14,480 something that's becoming a very 99 00:03:20,309 --> 00:03:18,319 valuable diagnostic tool and and your uh 100 00:03:22,949 --> 00:03:20,319 ophthalmology clinic it's used for 101 00:03:24,309 --> 00:03:22,959 detecting and monitoring such diseases 102 00:03:26,630 --> 00:03:24,319 as glaucoma 103 00:03:28,309 --> 00:03:26,640 uh other optic nerve diseases as well 104 00:03:29,430 --> 00:03:28,319 and for looking at changes within the 105 00:03:35,350 --> 00:03:29,440 macula 106 00:03:37,110 --> 00:03:35,360 forms of retinal diseases okay so so 107 00:03:39,350 --> 00:03:37,120 this should be at least familiar to some 108 00:03:41,110 --> 00:03:39,360 people here on the ground already yeah i 109 00:03:42,390 --> 00:03:41,120 would think so okay but probably the 110 00:03:44,470 --> 00:03:42,400 first time that we had one in space i'm 111 00:03:46,070 --> 00:03:44,480 guessing how i know we've been doing 112 00:03:47,430 --> 00:03:46,080 these for a little while now so are you 113 00:03:49,509 --> 00:03:47,440 starting to get good results back 114 00:03:51,270 --> 00:03:49,519 helpful helpful data yes the crew has 115 00:03:52,789 --> 00:03:51,280 been amazing we have with the very 116 00:03:55,830 --> 00:03:52,799 little training that they get they've 117 00:03:58,149 --> 00:03:55,840 done an excellent job performing oct 118 00:03:59,910 --> 00:03:58,159 on orbit and we're we're getting some 119 00:04:01,830 --> 00:03:59,920 useful data it's very limited data at 120 00:04:03,750 --> 00:04:01,840 this point but we are getting some 121 00:04:05,509 --> 00:04:03,760 useful data showing uh 122 00:04:08,470 --> 00:04:05,519 some of the structural changes to the 123 00:04:10,710 --> 00:04:08,480 eye as a result of microgravity exposure 124 00:04:12,149 --> 00:04:10,720 are you getting in uh are you 125 00:04:13,750 --> 00:04:12,159 able to come up with any insight into 126 00:04:15,670 --> 00:04:13,760 exactly what's happening 127 00:04:17,270 --> 00:04:15,680 at this point we really don't know the 128 00:04:19,270 --> 00:04:17,280 the data is fairly limited although 129 00:04:21,349 --> 00:04:19,280 there's some theories that have been uh 130 00:04:23,110 --> 00:04:21,359 suggested one being that 131 00:04:25,270 --> 00:04:23,120 the swelling of the optic nerve and 132 00:04:26,710 --> 00:04:25,280 these changes to the to the retina as 133 00:04:28,790 --> 00:04:26,720 well as flattening of the back of the 134 00:04:31,590 --> 00:04:28,800 eye of the globe 135 00:04:33,350 --> 00:04:31,600 may be a result of elevated pressure 136 00:04:35,270 --> 00:04:33,360 behind the eye within the optic nerve 137 00:04:37,430 --> 00:04:35,280 sheath 138 00:04:40,469 --> 00:04:37,440 so i'll localize 139 00:04:43,350 --> 00:04:40,479 pressure changes due to fluid shifts 140 00:04:46,550 --> 00:04:43,360 which are experienced in microgravity uh 141 00:04:48,230 --> 00:04:46,560 also another theory is that uh 142 00:04:50,150 --> 00:04:48,240 there may be elevated intracranial 143 00:04:51,590 --> 00:04:50,160 pressure within the brain that may be 144 00:04:53,430 --> 00:04:51,600 responsible some of the for some of 145 00:04:55,030 --> 00:04:53,440 these changes there's a condition 146 00:04:56,950 --> 00:04:55,040 terrestrially known as idiopathic 147 00:04:58,870 --> 00:04:56,960 intracranial hypertension which 148 00:05:00,629 --> 00:04:58,880 has its similarities that we see in the 149 00:05:02,550 --> 00:05:00,639 space flight syndrome yet there are some 150 00:05:04,550 --> 00:05:02,560 differences as well and in that 151 00:05:06,870 --> 00:05:04,560 particular condition we see 152 00:05:09,189 --> 00:05:06,880 swelling of the optic nerve uh what we 153 00:05:11,350 --> 00:05:09,199 call papilloedema we see 154 00:05:13,510 --> 00:05:11,360 extension of the optic nerve sheath 155 00:05:16,150 --> 00:05:13,520 flattening of the globe 156 00:05:17,909 --> 00:05:16,160 and typically terrestrially that disease 157 00:05:20,070 --> 00:05:17,919 as a result of elevated intracranial 158 00:05:21,350 --> 00:05:20,080 pressure so there are some similarities 159 00:05:24,310 --> 00:05:21,360 yet differences 160 00:05:27,350 --> 00:05:24,320 from that particular disease okay and i 161 00:05:29,270 --> 00:05:27,360 guess does this machine help us narrow 162 00:05:31,350 --> 00:05:29,280 down the possibilities of what's going 163 00:05:33,029 --> 00:05:31,360 on or is it just help us 164 00:05:34,950 --> 00:05:33,039 understand what's going on 165 00:05:36,550 --> 00:05:34,960 i think both it's going to help us 166 00:05:37,909 --> 00:05:36,560 understand the structural changes that 167 00:05:39,189 --> 00:05:37,919 we're seeing and 168 00:05:41,189 --> 00:05:39,199 hopefully help us determine the 169 00:05:43,350 --> 00:05:41,199 mechanisms for these changes 170 00:05:46,710 --> 00:05:43,360 again whether it be localized effects or 171 00:05:48,629 --> 00:05:46,720 maybe elevated intracranial pressure 172 00:05:50,150 --> 00:05:48,639 but it's also a very useful clinical 173 00:05:52,390 --> 00:05:50,160 tool for 174 00:05:55,430 --> 00:05:52,400 for diagnosing these these changes and 175 00:05:56,550 --> 00:05:55,440 monitoring these changes over time okay 176 00:05:58,790 --> 00:05:56,560 all right i think now we're going to get 177 00:06:01,189 --> 00:05:58,800 a demonstration right 178 00:06:02,950 --> 00:06:01,199 we'll do it okay great all you have to 179 00:06:05,590 --> 00:06:02,960 do is you're going to see a bunch of 180 00:06:21,270 --> 00:06:05,600 blue lines just focus on the 181 00:06:24,950 --> 00:06:23,110 okay you can sit back 182 00:06:27,590 --> 00:06:24,960 all right 183 00:06:29,110 --> 00:06:27,600 here's a video of your eye brandi 184 00:06:30,150 --> 00:06:29,120 if you look up here close enough you'll 185 00:06:33,590 --> 00:06:30,160 be able to 186 00:06:37,189 --> 00:06:35,189 can you see moving in the blood vessel 187 00:06:38,550 --> 00:06:37,199 those are your blood cells okay forcing 188 00:06:39,990 --> 00:06:38,560 through the vessel 189 00:06:41,830 --> 00:06:40,000 it's kind of hard to see but if you look 190 00:06:44,070 --> 00:06:41,840 you can see it 191 00:06:45,670 --> 00:06:44,080 so i haven't been to space obviously so 192 00:06:47,270 --> 00:06:45,680 i wouldn't have anything that you 193 00:06:48,870 --> 00:06:47,280 probably are looking for i'm guessing or 194 00:06:51,189 --> 00:06:48,880 is there not actually what we're more 195 00:06:53,029 --> 00:06:51,199 interested in with videos looking at the 196 00:06:55,350 --> 00:06:53,039 the uh what we call spontaneous venus 197 00:06:57,589 --> 00:06:55,360 pulsations 80 of the population has a 198 00:06:58,790 --> 00:06:57,599 spontaneous venus pulsation 199 00:07:00,950 --> 00:06:58,800 uh 200 00:07:02,309 --> 00:07:00,960 and you have one yourself you have a 201 00:07:04,550 --> 00:07:02,319 nice pulse hitting 202 00:07:07,189 --> 00:07:04,560 central vein right here if you look real 203 00:07:09,029 --> 00:07:07,199 close you can see it pulsating 204 00:07:11,350 --> 00:07:09,039 again 80 of the population has that 205 00:07:13,189 --> 00:07:11,360 that's that's considered normal okay uh 206 00:07:15,589 --> 00:07:13,199 if you have a spontaneous venous 207 00:07:17,909 --> 00:07:15,599 pulsation however and all of a sudden 208 00:07:20,150 --> 00:07:17,919 disappears that's not normal it could be 209 00:07:22,390 --> 00:07:20,160 indicative of elevated pressure 210 00:07:25,110 --> 00:07:22,400 behind the eye or even elevated pressure 211 00:07:26,950 --> 00:07:25,120 within the within the brain okay 212 00:07:28,469 --> 00:07:26,960 well thank you so much for for showing 213 00:07:31,350 --> 00:07:28,479 us this and giving us the demonstration 214 00:07:33,270 --> 00:07:31,360 it's very interesting and i i think 215 00:07:35,990 --> 00:07:33,280 i think it helps us understand a whole 216 00:07:37,589 --> 00:07:36,000 lot better what the crew is doing on 217 00:07:38,950 --> 00:07:37,599 orbit to find out more about their own 218 00:07:40,950 --> 00:07:38,960 eyes so 219 00:07:43,990 --> 00:07:40,960 really appreciate it again this was bob 220 00:07:46,469 --> 00:07:44,000 gibson talking with us inside the flight 221 00:07:47,830 --> 00:07:46,479 medicine optometry clinic at the johnson